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The effect of hypertension, which is known to enhance atherosclerosis, on acid esterase activity of rat aortic wall was studied histochemically. The purpose was to test our notion that atherogenesis depends on the balance between supply of lipids to the arterial smooth muscle cells and the lysosomal esterase activities. Hypertension was produced in rats by unilateral nephrectomy and administration of desoxycorticosterone acetate and sodium chloride. The animals reacted with varying degrees of hypertension. In rats with hypertension of a sufficiently high degree and of long duration, inhibition of aortic acid esterase activities occurred. No inhibition of these enzymes occurred in the other organs examined.
E Gaton, and
D Ben-Ishay, and
M Wolman
November 1946,
Experimental medicine and surgery,
E Gaton, and
D Ben-Ishay, and
M Wolman
January 1965,
Acta biologiae experimentalis,
E Gaton, and
D Ben-Ishay, and
M Wolman
January 1976,
Acta biologica et medica Germanica,
E Gaton, and
D Ben-Ishay, and
M Wolman
January 1958,
Surgical forum,
E Gaton, and
D Ben-Ishay, and
M Wolman
June 1965,
Science (New York, N.Y.),
E Gaton, and
D Ben-Ishay, and
M Wolman
July 1957,
Surgery, gynecology & obstetrics,
E Gaton, and
D Ben-Ishay, and
M Wolman
January 1978,
The Journal of preventive dentistry,
E Gaton, and
D Ben-Ishay, and
M Wolman
February 1951,
The American journal of psychiatry,
E Gaton, and
D Ben-Ishay, and
M Wolman
December 1968,
Japanese circulation journal,
E Gaton, and
D Ben-Ishay, and
M Wolman
January 1963,
Izvestiia na Mikrobiologicheskiia institut,
