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Ten healthy volunteers received a single oral dose of 100 mg nomifensive, a new antidepressant (tetragtdriusiqyubikube deruvatuve; Hoe 36-984). The drug-induced effects on the EEG were compared with those of placebo. The statistically proved results show that nomifensine causes a distinct shift in vigilance with two different partial processes. After an initially occurring stabilization of the dominant alpha-frequency there appears a polyrhythmic disintegration of the alpha-rhythm with increase of slower and faster frequencies. At the same time a shifting takes place within the beta-range with increasing of 23.5-32.0 Hz-components. Accordingly it is evident that nomifensine results in a typical pharmaco-electroencephalographic profile.
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
June 1981,
Klinische Wochenschrift,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
June 1975,
International journal of clinical pharmacology and biopharmacy,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
July 1978,
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
November 1980,
Pharmakopsychiatrie, Neuro-Psychopharmakologie,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
February 1980,
Kokyu to junkan. Respiration & circulation,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
January 1979,
L'Encephale,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
April 1978,
No shinkei geka. Neurological surgery,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
April 1982,
Biomedizinische Technik. Biomedical engineering,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
March 1978,
Medizinische Klinik,
D Bente, and
K Frick, and
M Lewinsky, and
J Penning, and
W Scheuler
August 1976,
Ceskoslovenska psychiatrie,
