Sixty-three male college students were assessed on the number of aversive sound blasts they administered in response to their fictitious task partner's blasts in a variation of the Taylor aggression paradigm. Subjects were randomly assigned to one of three alcohol dosing conditions (placebo, placebo/expect alcohol, and alcohol) and one of three instruction conditions (aggression-told the noise blasts were meant to disrupt task performance; altruism-told the noise blasts were meant to improve concentration; ambiguous-either aggression or altruism). A significant three-way interaction of dosing condition by instruction by subjects' sensation seeking was found, such that high sensation seekers in the alcohol condition, compared to low sensation seekers, delivered more noise blasts in the aggression instruction condition, whereas they administered fewer blasts in the altruism condition. High sensation seekers in the placebo condition yielded an opposite pattern of results. The results were interpreted in terms of the effects of "alcohol myopia" on the disinhibition of socially disapproved behaviors and in terms of the moderating effects of personality and situational factors.