Biomaterial Database

Relationship between cell size, plasma cholesterol and rat adipocyte cholesterol storage. 1976

B R Krause, and A D Hartman

Plasma cholesterol and cholesterol storage/10(6) adipocytes were determined in the epididymal, perirenal, subcutaneous, and mesenteric fat depots of the fasted male rat. Adipocyte cholesterol increased exponentially as functions of mean cell diameter, body weight, and cell size (mug triacylglycerol/cell) in all depots examined, whereas plasma cholesterol was best described as a parabolic function of body weight. In all but the mesenteric depot, expression of storage as a ratio of cellular cholesterol:triacylglycerol was also described as a parabolic function of body weight, resulting in curves parallel to the cholesterol-body weight relationship. It is suggested that (1) adipose tissue cholesterol storage is most rapid after adipocyte number becomes fixed, (2) the level of cholesterol in the plasma may be a major determinant of fat cell cholesterol storage, especially in subcutaneous cells from adult animals in which cell size is constant but cholesterol storage continues to increase, and (3) the effect of plasma cholesterol is less pronounced in mesenteric adipocytes.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D008643	Mesentery	A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.	Mesenteries
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D004822	Epididymis	The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
D000273	Adipose Tissue	Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.	Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D014280	Triglycerides	An ester formed from GLYCEROL and three fatty acid groups.	Triacylglycerol,Triacylglycerols,Triglyceride