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A closed loop closed batch dialysate delivery system was used to determine whether Na or K has an action on the renin-angiotensin system apart from volume changes. Twenty-eight patients on chronic haemodialysis were studied, 12 (group I) were normotensive and 16 (group II) had poorly controlled hypertension. Acute Na depletion or repletion (delta NA), AND K loss (delta K) were induced with or without net water loss. Net electrolyte and water movement across the dialysis membrane could be precisely quantitated.
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