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Diazepam (DZP) pretreatment (100mg/kg, ip) of rats 6 h before pentobarbital administration (45 mg/kg, ip) prolonged the barbiturate-induced narcosis. The concentrations of [14C]pentobarbital and total pentobarbital derivatives in blood or brain showed no differences between control and DZP-pretreated animals. The brain and blood concentrations of pentobarbital, when measured at a time corresponding to the respective arousal times from pentobarbital narcosis, were lower in the DZP-pretreated group. These results indicate that acute DZP pretreatment increases the sensitivity of the rat brain to pentobarbital rather than inducing changes in the disposition of the barbiturate.
L de Repentigny, and
G K Hanasono, and
G L Plaa
August 1979,
Indian journal of experimental biology,
L de Repentigny, and
G K Hanasono, and
G L Plaa
January 1990,
Archives internationales de pharmacodynamie et de therapie,
L de Repentigny, and
G K Hanasono, and
G L Plaa
April 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
L de Repentigny, and
G K Hanasono, and
G L Plaa
October 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
L de Repentigny, and
G K Hanasono, and
G L Plaa
January 1974,
Research communications in chemical pathology and pharmacology,
L de Repentigny, and
G K Hanasono, and
G L Plaa
August 1979,
Journal of pharmaceutical sciences,
L de Repentigny, and
G K Hanasono, and
G L Plaa
January 1983,
Journal of toxicology and environmental health,
L de Repentigny, and
G K Hanasono, and
G L Plaa
January 1979,
European journal of drug metabolism and pharmacokinetics,
L de Repentigny, and
G K Hanasono, and
G L Plaa
October 2017,
Toxicology letters,
L de Repentigny, and
G K Hanasono, and
G L Plaa
March 1986,
Arzneimittel-Forschung,
