DNA typing for HLA class H presents quality typing which improves kidney graft survival. Discrepancy between serological and molecular biological typing of major histocompatibility complex varies from ten to fifteen percent according to the European Tissue Typing Laboratories. In conditions of Regional Tissue Typing Laboratory we started with molecular HLA-DR typing in the beginning of 1997. One of the reasons was large activity of Regional Transplantation Centre in University Hospital and as we mentioned before quality of molecular HLA typing. Till November 1997 we took and typed 43 donors organs and we transplanted about 57 kidneys and 3 livers. That was why to introduce molecular biological methods of HLA-DR typing into the practical life of laboratory especially on duties seemed to be very advisable. We compare serological and PCR-SSP methods in group of 30 cadaveric donors in this article. The age median of our group was 36.5 yrs, the ratio men-women was 20:10.