-transparent.png){kind=logo}
The values of the pharmacokinetic parameters of the nucleoside antiretroviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine (D-D4FC) in rhesus monkeys were determined with a two-compartment model after the administration of a single dose. The average values for the terminal half-life, renal clearance, and total systemic clearance for the intravenous administration route were 3.6 h and 0.31 and 0.43 liter.kg-1.h-1, respectively. The oral bioavailability of D-D4FC averaged 41%. For the intravenous administration route, 76% of the compound was recovered intact in the urine within 8 h, indicating that D-D4FC was eliminated mainly by renal excretion. D-D4FC was detected in the cerebrospinal fluid (CSF) at similar concentrations after administration by both the intravenous and oral routes. D-D4FC levels in plasma and CSF were higher than the median effective concentration for human immunodeficiency virus type 1 in vitro.
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
July 2005,
Antimicrobial agents and chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
April 1999,
Antimicrobial agents and chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
February 2005,
Antimicrobial agents and chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
April 2001,
Antimicrobial agents and chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
February 1995,
Immunopharmacology and immunotoxicology,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
January 2000,
Antimicrobial agents and chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
January 2003,
Antiviral chemistry & chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
July 1998,
Antimicrobial agents and chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
August 2007,
Antimicrobial agents and chemotherapy,
L Ma, and
S J Hurwitz, and
J Shi, and
J J Mcatee, and
D C Liotta, and
H M McClure, and
R F Schinazi
January 1993,
Drug metabolism and disposition: the biological fate of chemicals,
