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Activity of a heat-induced reformulation of amphotericin B deoxycholate (fungizone) against Leishmania donovani. 1999
Laboratoire de Physicochimie Biomoléculaire et Cellulaire (CNRS ESA 7033), Université Pierre et Marie Curie, Paris, France.
The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.
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