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Modulation of nitric oxide production by tetracyclines and chemically modified tetracyclines. 1998
E Cillari, and
S Milano, and
P D'Agostino, and
G Di Bella, and
M La Rosa, and
C Barbera, and
V Ferlazzo, and
G Cammarata, and
S Grimaudo, and
M Tolomeo, and
S Feo
Institute of General Pathology, University of Palermo, Italy.
Chemically modified tetracyclines (CMTs) dose-dependently decreased inducible nitric oxide synthase (iNOS) and, consequently, nitric oxide (NO) formation by the lipopolysaccharide (LPS)-stimulated J774 line. The inhibitory effect was due to a specific reduction in the iNOS protein content in the cells, as attested by Western blot analysis and by the inhibition of iNOS mRNA accumulation. Furthermore, CMTs cause a dose-dependent increase in cell death in the J774 line mediated by the NO-independent apoptotic mechanism.
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