Biomaterial Database

Influence of different adrenoceptor agonists and antagonists on physostigmine-induced yawning in rats. 1999

M R Zarrindast, and S Fazli-Tabai, and S Semnanian, and Y Fathollahi

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran.

In the present study, effects of adrenoceptor agonists and antagonists on physostigmine-induced yawning was investigated. Intraperitoneal (i.p.) injection of different doses of physostigmine (0.03, 0.05, 0.1, and 0.2 mg/kg) induced yawning in rats. The maximum response was obtained by 0.2 mg/kg of the drug. The alpha1-adrenoceptor agonist, phenylephrine, and the alpha2-adrenoceptor agonist, clonidine, decreased yawning induced by physostigmine. Prazosin and higher doses of phenoxybenzamine reduced the inhibitory effect of phenylephrine. Higher doses of yohimbine also reduced the clonidine response. The adrenoceptor antagonists, prazosin, phenoxybenzamine, and propranolol, did not significantly alter the physostigmine response. However, yohimbine, or lower doses of prazosin, decreased the physostigmine response. It may be concluded that alpha1- and alpha2-adrenoceptor stimulation decreases the physostigmine-induced yawning behavior in rats.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010830	Physostigmine	A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.	Eserine
D004347	Drug Interactions	The action of a drug that may affect the activity, metabolism, or toxicity of another drug.	Drug Interaction,Interaction, Drug,Interactions, Drug
D000322	Adrenergic Agonists	Drugs that bind to and activate adrenergic receptors.	Adrenomimetics,Adrenergic Agonist,Adrenergic Receptor Agonist,Adrenergic Receptor Agonists,Receptor Agonists, Adrenergic,Agonist, Adrenergic,Agonist, Adrenergic Receptor,Agonists, Adrenergic,Agonists, Adrenergic Receptor,Receptor Agonist, Adrenergic
D000704	Analysis of Variance	A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.	ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015000	Yawning	An involuntary deep INHALATION with the MOUTH open, often accompanied by the act of stretching.	Yawnings
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018674	Adrenergic Antagonists	Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.	Adrenergic-Blocking Agents,Adrenolytics,Antiadrenergic Agents,Adrenergic Antagonist,Adrenergic Blockaders,Adrenergic Blocker,Adrenergic Blockers,Adrenergic Receptor Antagonists,Adrenergic Receptor Blockaders,Adrenolytic Agents,Adrenolytic Drugs,Anti-Adrenergics,Antiadrenergics,Receptor Antagonists, Adrenergic,Adrenergic Blocking Agents,Agents, Adrenergic-Blocking,Agents, Adrenolytic,Agents, Antiadrenergic,Antagonist, Adrenergic,Antagonists, Adrenergic,Antagonists, Adrenergic Receptor,Anti Adrenergics,Blockaders, Adrenergic,Blockaders, Adrenergic Receptor,Blocker, Adrenergic,Blockers, Adrenergic,Drugs, Adrenolytic,Receptor Blockaders, Adrenergic