BACKGROUND With a view to preventing the sequelae of conventional subtotal resection of stomach, such as dumping syndrome, intestinal fluid reflux and other such complications and maintaining the normal movable physiological function of the remnant stomach, we have designed a pylorus and pyloric vagus preserving gastrectomy (PPVPG). METHODS As many as 125 cases of peptic ulcer (GU 49, DU 76) were so treated without a single death. Comparative studies were made with 48 cases of operations done at the same period with Billroth. In reducing acid, both modes of operations are identical. RESULTS 97.9% of the Billroth cases saw more than two degrees of intestinal fluid reflux, 5.8% of the PPVPG cases had only one. Dumping syndrome occurred in the Billroth cases, none in PPVPG cases. In gastric emptying, food digestion and absorption, body weight and life quality, PPVPG proved superior to Billroth. In the subsequent follow-ups for 5.5 years, no recurrence of the disorder has been reported, curative effect proved to be Visik I or II, 98.4%. CONCLUSIONS Safe and adaptable to a wide variety of indications, PPVPG carves not only a new course for the surgical treatment of peptic ulcer, but also can be applied to other benign gastric lesion such as polyposis, leiomyoma and ectopic pancreas.