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Brain injury (BI) was induced in 9 rabbits either after cranial trepanation or through graded blow. Cell-mediated immunity to brain autoantigens in the automix-culture test and the production of specific antibodies on soluble protein antigen immunization were studied. Experiment BI was not found to result in the emergence of the lymphocytes capable of mediate cellular autoimmune responses. However, there were increases in the nonspecific lymphocytic sensitivity to the T-lymphocytic mitogen ConA and in a humoral immune response, suggesting the activation of T- and B-cell immunity following BI.
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