Diffusion-limited ion flow through pores. 1976

P Läuger

If the permeability of an ion channel is high, the overall transport becomes ultimately limited by the rate with which ions from the aqueous phase arrive at the mouth of the channel. In this study a theoretical treatment of diffusion-limited ion transport through pores is given which takes both concentration and electric potential gradients into account as driving forces for the flow of ions. The current-voltage characteristic of a diffusion-limited channel is found to be strongly saturating. Addition of an impermeable elesults from a reduction in the electric field strength near the mouth of the channel. At low voltages the permeability P of the pore is obtaines as 1/P =(1/Pi)+(1/P'c)+(1/P''c) where Pi is the intrinsic permeability and P'c, P''c are the left-hand and right-hand convergence permeabilities, respectivelyl which are proportional to the aqueous diffusion coefficient of the permeable ion and to the effective capture radius of the pore.

UI MeSH Term Description Entries
D007477 Ions An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
D008433 Mathematics The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Mathematic
D008567 Membranes, Artificial Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION. Artificial Membranes,Artificial Membrane,Membrane, Artificial
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D010539 Permeability Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions. Permeabilities
D004058 Diffusion The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT. Diffusions
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic

Related Publications

P Läuger
January 1987, The Journal of experimental zoology. Supplement : published under auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry,
P Läuger
October 2017, The journal of physical chemistry. B,
P Läuger
January 1987, The Journal of experimental zoology. Supplement : published under auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry,
P Läuger
June 1974, Biophysical journal,
P Läuger
July 2016, Biochimica et biophysica acta,
P Läuger
July 2006, Physical review letters,
P Läuger
August 1978, Journal of theoretical biology,
Copied contents to your clipboard!