-transparent.png){kind=logo}
OBJECTIVE To study the inhibitory effects of copper-aspirin complex (CuAsp) on platelet aggregation. METHODS With adenosine diphosphate the effects of CuAsp on platelet aggregation in vitro or in vivo were investigated. Radioimmunoassay and fluorophotometry were used to measure thromboxane B2 (TXB2) generation from platelets, the levels of TXB2 and of 6-keto-PGF1 alpha in plasma and the platelet serotonin release reaction. RESULTS In vitro, CuAsp inhibited arachidonic acid (AA)-induced aggregation (IC50 = 17 mumol.L-1, 95% confidence limits: 9-33 mumol.L-1), the release of 5-HT (IC50 = 19 mumol.L-1, 95% confidence limits: 10-30 mumol.L-1), and TXB2 generation from platelets (P < 0.05). CuAsp 10 mg.kg-1 i.g. selectively inhibited AA-induced aggregation, and increased the 6-keto-PGF1 alpha concentration in plasma while decreased that of TXB2. CONCLUSIONS CuAsp, in vitro or in vivo, shows more potent inhibitory effects on AA-induced aggregation than aspirin (Asp), related to the inhibition of platelet cyclooxygenase and the release of active substances from platelets.
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
September 1988,
Clinical pharmacology and therapeutics,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
December 2018,
Zhongguo shi yan xue ye xue za zhi,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
September 2000,
Thrombosis research,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
September 1985,
American journal of veterinary research,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
March 1997,
The Annals of pharmacotherapy,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
November 1997,
Human & experimental toxicology,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
March 1998,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
November 1986,
Research communications in chemical pathology and pharmacology,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
January 1980,
International pharmacopsychiatry,
Z Q Shen, and
Z H Chen, and
G Y Ma, and
D C Wang, and
W L Wu, and
W P Liu, and
Y K Yang, and
H Z Xiong
November 2020,
Platelets,
