-transparent.png){kind=logo}
The effects of chlorpromazine (CPZ) and imipramine (IMP) on platelet aggregation in vitro were investigated. Both CPZ and IMP inhibited epinephrine-induced secondary aggregation in a dose-dependent fashion and changed adenosine diphosphate (ADP)-induced irreversible aggregation into a reversible response in human platelets. With rabbit platelets, CPZ (0.6-20 microM) and IMP (6-60 microM) showed a selective inhibitory effect on the aggregation by collagen, whereas, even at 200 microM, this effect was found neither in arachidonic acid (AA)-induced aggregation nor in ADP-induced one. CPZ and IMP also inhibited human platelet aggregations induced by collagen, but not by AA. The antiaggregating action of CPZ and IMP was thought to be due to their inhibitory effects on AA liberation from platelet membranes, suggesting that they might inhibit participating enzymes (phospholipase A2, C or lipase) or the process of the activation of the enzymes.
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
March 1998,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
December 1978,
British journal of clinical pharmacology,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
November 1997,
Human & experimental toxicology,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
July 1997,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
February 1967,
Archives internationales de pharmacodynamie et de therapie,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
January 1984,
Biomedica biochimica acta,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
March 1992,
Arzneimittel-Forschung,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
March 2015,
Biomolecules & therapeutics,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
June 2017,
Biochemical and biophysical research communications,
J Ishigooka, and
K Tanaka, and
Y Suzuki, and
M Katori, and
S Miura
January 1976,
Farmakologiia i toksikologiia,
