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OBJECTIVE To study the influence of carbamazepine (Car) on GABA effect in hippocampus. METHODS Evoked potentials were recorded on pyramidal cells in CA1 after stimulation (0.5 Hz, 50 microseconds) to Schaffer collaterals in rat hippocampal slices (350 microns). RESULTS Car 0.1 and 0.2 mmol.L-1 did not affect field potentials, whereas Car 0.2 mmol.L-1 plus GABA (0.1-1 mmol.L-1) gave rise to a stronger inhibition on field potentials than that of GABA alone. Bicuculline did not reverse Car facilitation on GABA inhibition on field potentials. (-)-Baclofen was more effective in inhibiting field potentials than GABA. Car 0.2 mmol.L-1 plus (-)-baclofen (1-5 mumol.L-1) brought an inhibition stronger than that of (-)-baclofen alone. CONCLUSIONS Car facilitates the effects of GABA on pyramidal cells in hippocampal CA1 region, probably related to GABAB receptors.
J D Zhang, and
K Saito
April 1998,
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J D Zhang, and
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J D Zhang, and
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J D Zhang, and
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J D Zhang, and
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J D Zhang, and
K Saito
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J D Zhang, and
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June 2000,
Canadian journal of physiology and pharmacology,
