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Serotonin (5-HT), prostaglandin E1 (PGE1) or a bacterial pyrogen (E. coli or S. typhosa) was microinjected in a volume of 1.0--1.5 microliter into the hypothalamus of the unanesthetized monkey to evoke a long-term hyperthermia. Samples of venous blood collected every 15 min, before, during and after each fever were analyzed by radioimmunoassay for plasma thyroxin levels. There was no statistically significant correlation between plasma thyroxin values and a given phase of the hyperthermic episode induced by the microinjections of 5--HT, PGE1 or bacteria. The possibility that an enhanced release of the thyroid hormone serves to sustain a long-term elevation in temperature evoked by a centrally acting pyrogenic substance is not supported.
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
January 1973,
Acta physiologica Polonica,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
January 1969,
Experientia,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
June 1975,
Research communications in chemical pathology and pharmacology,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
December 1965,
The Journal of physiology,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
October 1991,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
November 1974,
Research communications in chemical pathology and pharmacology,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
January 1969,
Acta physiologica Academiae Scientiarum Hungaricae,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
January 1991,
The American journal of physiology,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
January 1976,
Brain research bulletin,
C W Simpson, and
W D Ruwe, and
P V Malven, and
R D Myers
October 1990,
Clinica chimica acta; international journal of clinical chemistry,
