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Twelve subjects with progressive myoclonus epilepsy (PME) were studied with transcranial magnetic stimulation (TMS), using single and paired magnetic stimuli at different interstimulus intervals (ISIs), and polygraphic recording. Motor threshold (T) and silent period (SP) were normal. Paired TMS showed a loss of inhibition at 100-150 ms ISI and a marked facilitation at 50 ms ISI of conditioned motor evoked potential (MEP). Polygraphic analysis showed 20 Hz oscillatory activity over the sensorimotor area coupled to contralateral myoclonic jerks. These findings suggest a condition of increased supraspinal excitability and support the evidence of a cortical rhythm in the range of 20 Hz. No direct evidence exists that these findings are mediated by the same intracortical pathway. Furthermore, the normal SP and T suggest that the abnormal excitability is not a constant feature but is evident during rhythmic events.
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
January 1993,
Neurology,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
September 2023,
Epilepsia,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
January 2006,
Neurophysiologie clinique = Clinical neurophysiology,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
January 2003,
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
March 2007,
Headache,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
June 2018,
Brain research bulletin,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
November 2003,
Epilepsy currents,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
August 2008,
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
January 1999,
Electroencephalography and clinical neurophysiology. Supplement,
F Valzania, and
A P Strafella, and
A Tropeani, and
G Rubboli, and
S A Nassetti, and
C A Tassinari
May 2003,
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
