Biomaterial Database

Expression of vascular endothelial growth factor in cerebellar hemangioblastomas does not correlate with tumor angiogenesis. 1998

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Neurosciences Research Unit of the Mapfre-Medicine Foundation (Laboratory of Experimental Neurooncology), Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.

The relation between angiogenesis and tissue expression of vascular endothelial growth factor (VEGF) was studied in a series of 14 capillary cerebellar hemangioblastomas. In the present series, the number of intratumoral microvessels, identified by the endothelial marker CD34, does not correlate with the degree of VEGF expression. This finding suggests that endothelial growth factors other than VEGF may regulate tumor angiogenesis in these neoplasms.

UI	MeSH Term	Description	Entries
D007150	Immunohistochemistry	Histochemical localization of immunoreactive substances using labeled antibodies as reagents.	Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008222	Lymphokines	Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.	Lymphocyte Mediators,Mediators, Lymphocyte
D009389	Neovascularization, Pathologic	A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.	Angiogenesis, Pathologic,Angiogenesis, Pathological,Neovascularization, Pathological,Pathologic Angiogenesis,Pathologic Neovascularization,Pathological Angiogenesis,Pathological Neovascularization
D002528	Cerebellar Neoplasms	Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)	Benign Cerebellar Neoplasms,Cerebellar Cancer,Malignant Cerebellar Neoplasms,Cerebellar Neoplasms, Benign,Cerebellar Neoplasms, Malignant,Cerebellar Neoplasms, Primary,Cerebellar Tumors,Neoplasms, Cerebellar,Neoplasms, Cerebellar, Benign,Neoplasms, Cerebellar, Malignant,Neoplasms, Cerebellar, Primary,Primary Neoplasms, Cerebellum,Benign Cerebellar Neoplasm,Cancer, Cerebellar,Cerebellar Cancers,Cerebellar Neoplasm,Cerebellar Neoplasm, Benign,Cerebellar Neoplasm, Malignant,Cerebellar Neoplasm, Primary,Cerebellar Tumor,Cerebellum Primary Neoplasm,Cerebellum Primary Neoplasms,Malignant Cerebellar Neoplasm,Neoplasm, Benign Cerebellar,Neoplasm, Cerebellar,Neoplasm, Cerebellum Primary,Neoplasm, Malignant Cerebellar,Primary Cerebellar Neoplasm,Primary Cerebellar Neoplasms,Primary Neoplasm, Cerebellum,Tumor, Cerebellar
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016228	Endothelial Growth Factors	These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.	Endothelial Cell-Derived Growth Factors,alpha-Endothelial Growth Factor,beta-Endothelial Growth Factor,ECDGF,Endo-GF,Endothelial Growth Factor,Endothelial Growth Factor Polypeptides,Endothelial Cell Derived Growth Factors,Growth Factor, Endothelial,Growth Factor, alpha-Endothelial,Growth Factor, beta-Endothelial,Growth Factors, Endothelial,alpha Endothelial Growth Factor,beta Endothelial Growth Factor
D042442	Vascular Endothelial Growth Factors	A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.	VEGFs
D042461	Vascular Endothelial Growth Factor A	The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.	Vascular Endothelial Growth Factor,Vascular Endothelial Growth Factor-A,GD-VEGF,Glioma-Derived Vascular Endothelial Cell Growth Factor,VEGF,VEGF-A,Vascular Permeability Factor,Vasculotropin,Glioma Derived Vascular Endothelial Cell Growth Factor,Permeability Factor, Vascular
D018325	Hemangioblastoma	A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)	Multiple Hemangioblastomas,Hemangioblastoma, Multiple,Hemangioblastomas,Hemangioblastomas, Multiple,Multiple Hemangioblastoma
D018952	Antigens, CD34	Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.	CD34 Antigens,CD34 Antigen,Antigen, CD34

Related Publications

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Angiogenesis does not correlate with prognosis or expression of vascular endothelial growth factor in synovial sarcomas.

January 1999, Oncology reports,

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Immunohistochemical expression of vascular endothelial growth factor (VEGF) does not correlate with microvessel density in renal cell carcinoma.

January 2007, Neoplasma,

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Celecoxib can induce vascular endothelial growth factor expression and tumor angiogenesis.

January 2011, Molecular cancer therapeutics,

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression.

March 1999, Journal of the National Cancer Institute,

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Association between vascular endothelial growth factor (VEGF) expression and tumor angiogenesis in ameloblastomas.

January 2002, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma.

June 1998, Clinical cancer research : an official journal of the American Association for Cancer Research,

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Vascular endothelial growth factor (VEGF) expression regulates angiogenesis accompanying tumor growth in a peritoneal disseminated tumor model.

January 2001, In vivo (Athens, Greece),

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis.

January 1996, Cancer research,

J Vaquero, and M Zurita, and S Coca, and C Salas, and S Oya

Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia.

August 1995, Journal of the National Cancer Institute,