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The possibility that polyphloretin phosphate (PPP) antagonizes the central effects elicited by prostaglandin (PG) E2 and F2alpha was investigated. PPP was administered i.c.v. to male Wistar rats (10 or 25 microgram) 10 or 30 min before i.c.v. injection of PGF2 or PGF2alpha (1 or 10 microgram). The duration of several component of behavior, the degree of irritability, and the rectal temperature of rats were measured; the levels of noradrenaline, dopamine, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid were measured spectrophoto-fluorometrically in discrete brain areas. PPP antagonized temperature and behaviroal changes induced in rats by PGF2alpha, but not those induced by PGE2. The magnitude of antagonism depended on the dose of PPP and on the time of the pretreatment before PGF2alpha administration. Changes in the level of biogenic amines in discrete brain areas evoked by PGs were not affected by PPP. We found that PPP antagonizes the central effects of PGF2alpha but not those of PGE2, and that changes of biogenic amines in discrete brain areas elicited by PGs are not specific.
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
January 1976,
Acta biologica et medica Germanica,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
December 1978,
Clinical science and molecular medicine. Supplement,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
April 1978,
Pflugers Archiv : European journal of physiology,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
September 1976,
Comprehensive therapy,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
February 1978,
Prostaglandins,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
November 1982,
Acta physiologica Scandinavica,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
January 1976,
Polish journal of pharmacology and pharmacy,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
May 1972,
Prostaglandins,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
January 1974,
Gynakologische Rundschau,
R Brus, and
Z S Herman, and
R Szkilnik, and
J Słominska-Zurek, and
J Zabawska, and
Z Jamrozik, and
A Kryk
January 1978,
Journal of dental research,
