Biomaterial Database

Effects of spermidine treatment on neurobehavioral development in intrauterine growth retarded (IUGR) rats. 1999

G Uzüm, and A S Diler, and Z Ziylan

Department of Physiology, Istanbul Medical Faculty, Capa, Turkey.

It was previously shown that polyamine treatment could induce precocious development of several somatic and neurobehavioral functions in newborn rats. This study investigates the effects of daily injections of spermidine (SPMD) 50 microl/10 g s.c. on neurobehavioral development of newborn rats experiencing undernutrition. Neurobehavioral development was assessed by measurements of gripping and righting reflexes. SPMD treated intrauterine growth retarded (IUGR) rats reached righting reflex control values at 30 days postnatal (1.87 +/- 0.78 s vs 1.75 +/- 0.66 s). Beginning from 7 days postnatal, gripping reflex values of SPMD treated IUGR rats declined, reaching that of controls at 30 days postnatal (1.77 +/- 91 degrees vs 1.82 +/- 65 degrees). These results suggest the utility of exogenous SPMD in rats experiencing undernutrition, thus indicating a clinical relevance.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D011187	Posture	The position or physical attitude of the body.	Postures
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011297	Prenatal Exposure Delayed Effects	The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.	Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D012018	Reflex	An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D005260	Female		Females
D005317	Fetal Growth Retardation	Failure of a FETUS to attain expected GROWTH.	Growth Retardation, Intrauterine,Intrauterine Growth Retardation,Fetal Growth Restriction,Intrauterine Growth Restriction
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013095	Spermidine	A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.