BIOMAT Database Logo BIOMAT Database Logo

[Aqueous-and serum levels of cephalexin and penicillin V after oral application in man (author's transl)]. 1979

T Engels, and J Ehrhorn, and H Bleckmann

This clinical study implies orally administered cephalexin and penicillin V as agents with effective aqueous homor penetration in noninfected human eyes. Aqueous humor concentration of cephalexin increases up to 15% of the serum level 2 h after application. Administration of 1 g or 2 g cephalexin revealed no significant difference in aqueous humor concentration. So penetration of blood-aqueous-humor barrier can be regarded as a saturation process. Individual results of 92 cephalexin determinations are variant and not related to body weight or age of the patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010404 Penicillin V A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms. Penicillin, Phenoxymethyl,Apocillin,Beromycin,Beromycin, Penicillin,Berromycin, Penicillin,Betapen,Fenoxymethylpenicillin,Pen VK,Penicillin V Potassium,Penicillin V Sodium,Penicillin VK,Phenoxymethylpenicillin,V-Cillin K,Vegacillin,Penicillin Beromycin,Penicillin Berromycin,Phenoxymethyl Penicillin,Potassium, Penicillin V,Sodium, Penicillin V,V Cillin K,V Sodium, Penicillin,VCillin K
D002387 Cataract Extraction The removal of a cataractous CRYSTALLINE LENS from the eye. Enzymatic Zonulolysis,Phakectomy,Cataract Extractions,Enzymatic Zonulolyses,Extraction, Cataract,Extractions, Cataract,Phakectomies,Zonulolyses, Enzymatic,Zonulolysis, Enzymatic
D002506 Cephalexin A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-,Cefalexin,Cephalexin Dihydride,Cephalexin Hemihydrate,Cephalexin Hydrochloride,Cephalexin Monohydrate,Cephalexin Monohydrochloride,Cephalexin Monohydrochloride, Monohydrate,Cephalexin, (6R-(6alpha,7alpha(R*)))-Isomer,Cephalexin, (6R-(6alpha,7beta(S*)))-Isomer,Cephalexin, (6R-(6alpha,7beta))-Isomer,Cephalexin, Monosodium Salt,Cephalexin, Monosodium Salt, (6R-(6alpha,7beta))-Isomer,Ceporexine,Palitrex
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001082 Aqueous Humor The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319) Aqueous Flare,Intraocular Fluid,Aqueous Flares,Aqueous Humors,Flare, Aqueous,Fluid, Intraocular,Fluids, Intraocular,Humor, Aqueous,Humors, Aqueous,Intraocular Fluids
D013530 Surgical Wound Infection Infection occurring at the site of a surgical incision. Postoperative Wound Infection,Infection, Postoperative Wound,Infection, Surgical Wound,Surgical Site Infection,Wound Infection, Postoperative,Wound Infection, Surgical,Infection, Surgical Site,Infections, Postoperative Wound,Infections, Surgical Site,Infections, Surgical Wound,Postoperative Wound Infections,Surgical Site Infections,Surgical Wound Infections,Wound Infections, Postoperative,Wound Infections, Surgical

Related Publications

T Engels, and J Ehrhorn, and H Bleckmann
[Penicillin levels in tonsillar tissue and serum after intramuscular and oral application (author's transl)].
October 1976, Laryngologie, Rhinologie, Otologie,
T Engels, and J Ehrhorn, and H Bleckmann
[Penicillin V potassium in tonsillar tissue and serum (author's transl)].
September 1975, MMW, Munchener medizinische Wochenschrift,
T Engels, and J Ehrhorn, and H Bleckmann
[Serum levels of cephazolin in man (author's transl)].
March 1973, Antibiotica,
T Engels, and J Ehrhorn, and H Bleckmann
[Oral cephalexin therapy of osteomyelitis (author's transl)].
February 1979, Wiener medizinische Wochenschrift (1946),
T Engels, and J Ehrhorn, and H Bleckmann
Tissue distribution and serum levels of cephalexin in man.
October 1970, Postgraduate medical journal,
T Engels, and J Ehrhorn, and H Bleckmann
[Blood levels of penicillin in infants after oral administration of penicillin V (phenoxymethyl penicillin)].
February 1956, Rivista di clinica pediatrica,
T Engels, and J Ehrhorn, and H Bleckmann
[Plasma levels of probucol in man after single and repeated oral doses (author's transl)].
October 1980, La Nouvelle presse medicale,
T Engels, and J Ehrhorn, and H Bleckmann
Serum levels of penicillin v after oral administration of pediatric preparations to healthy subjects.
May 1975, Acta paediatrica Scandinavica,
T Engels, and J Ehrhorn, and H Bleckmann
Cephalexin levels in serum, synovial fluid and joint tissues after oral administration.
January 1977, Scandinavian journal of rheumatology,
T Engels, and J Ehrhorn, and H Bleckmann
Antibacterial activity of serum after oral doses of triacetyloleandomycin, erythromycin, potassium penicillin V and penicillin V.
September 1958, Pediatrics,
Copied contents to your clipboard!