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1.2 mega U Penicillin V potassium was given to 20 patients 2 hours (group 1) and another 19 patients 3 hours (group 2) before tonsillectomy. After the operation biological determinations of the levels of active principle were made from tonsillar tissue and serum with statistical evaluation of the results (Spearman's rank correlation). There was a significant connection between the serum and tonsillar tissue concentrations (in children and adults) in both groups. The level of the active principle in group 2 was only slightly lower than in group 1. Many of the micro-organisms responsible for tonsillitis can be influenced by the concentrations found here, so that application of Penicillin V can often be expected to have a good therapeutic effect.
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
October 1976,
Laryngologie, Rhinologie, Otologie,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
February 1958,
Antibiotic medicine & clinical therapy (New York, NY),
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
April 1977,
Journal of the American Pharmaceutical Association,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
February 1979,
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
September 1958,
Pediatrics,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
May 1963,
Zeitschrift fur arztliche Fortbildung,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
February 1975,
Ceskoslovenska otolaryngologie,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
June 1959,
Arzneimittel-Forschung,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
September 1960,
Proceedings of the staff meetings. Mayo Clinic,
H Backmann, and
H Drees, and
D Geisen, and
K Mündnich, and
W Ritzerfeld
January 1977,
Allergie und Immunologie,
