Biomaterial Database

The effect of impulse noise exposure on distortion product otoacoustic emissions in the awake guinea pig. 2000

E Emmerich, and F Richter, and W Meissner, and H G Dieroff

Department of Physiology I, Medical Faculty of the Friedrich Schiller University of Jena, Germany. eemm@mti-n.uni-jena.de

Distortion product otoacoustic emissions (DPOAE) are a sensitive detector of outer hair cell (OHC) function and were monitored in awake guinea pigs before and after impulse noise damaging the cochlea (peak intensity 153 dB SPL, rise time < 0.1 ms). Animals had stable DPOAE levels before noise exposure. In the first hours after noise exposure DPOAE levels were reduced significantly. Three different patterns of recovery of DPOAE were seen in the post-exposure period:restitution exceeding controls, partial recovery and no recovery. In general, DPOAE levels declined and types of recovery closely corresponded to changes in amplitudes of cochlear microphonics after noise exposure. These data suggest that the monitoring of DPOAE is a suitable method for diagnosing impaired OHC function.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009622	Noise	Any sound which is unwanted or interferes with HEARING other sounds.	Noise Pollution,Noises,Pollution, Noise
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001305	Auditory Fatigue	Loss of sensitivity to sounds as a result of auditory stimulation, manifesting as a temporary shift in auditory threshold. The temporary threshold shift, TTS, is expressed in decibels.	Fatigue, Auditory,Temporary Threshold Shift, Auditory,Auditory Fatigues,Fatigues, Auditory
D012680	Sensitivity and Specificity	Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	Specificity,Sensitivity,Specificity and Sensitivity
D013018	Sound Spectrography	The graphic registration of the frequency and intensity of sounds, such as speech, infant crying, and animal vocalizations.	Sonography, Speech,Sonography, Sound,Speech Sonography,Sonographies, Sound,Sound Sonographies,Sound Sonography,Spectrography, Sound
D017084	Otoacoustic Emissions, Spontaneous	Self-generated faint acoustic signals from the inner ear (COCHLEA) without external stimulation. These faint signals can be recorded in the EAR CANAL and are indications of active OUTER AUDITORY HAIR CELLS. Spontaneous otoacoustic emissions are found in all classes of land vertebrates.	Spontaneous Otoacoustic Emissions,Otoacoustic Emission, Spontaneous,Spontaneous Otoacoustic Emission
D018072	Hair Cells, Auditory, Outer	Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.	Auditory Hair Cell, Outer,Auditory Hair Cells, Outer,Cochlear Outer Hair Cell,Cochlear Outer Hair Cells,Hair Cell, Auditory, Outer,Hair Cells, Auditory, Outer Inner,Outer Auditory Hair Cell,Outer Auditory Hair Cells,Outer Hair Cells,Hair Cells, Outer