BIOMAT Database Logo BIOMAT Database Logo

Long-term follow-up of premature infants treated with prophylactic, intratracheal recombinant human CuZn superoxide dismutase. 2000

J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Department of Pediatrics, Winthrop University Hospital, Mineola, NY 11501, USA.

OBJECTIVE To examine the long-term effects of treatment with recombinant human CuZn superoxide dismutase (rhSOD) in infants enrolled previously in two placebo-controlled trials. METHODS Records for 46 (88%) infants were examined, with 19 infants having received either single or multiple intratracheal (i.t.) doses of placebo, 12 having received a single i.t. dose of rhSOD, and 15 having received multiple i.t. doses of rhSOD. Mean age at follow-up was 28 months corrected age. Records were examined for neurologic dysfunction, developmental delay, and any significant medical disorders. RESULTS Four placebo infants (21%) had evidence of neurodevelopmental abnormalities and four infants developed asthma. Four single-dose rhSOD infants (33%) had neurodevelopmental abnormalities and two infants developed asthma. One multiple-dose rhSOD infant had evidence of neurodevelopmental abnormalities and one developed asthma. No other differences were found between the placebo and rhSOD groups. CONCLUSIONS Preliminary data suggest that rhSOD is safe and not associated with any long-term adverse effects. Further results will depend on the results of multicenter trials of rhSOD in preterm infants.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007235 Infant, Premature, Diseases Diseases that occur in PREMATURE INFANTS.
D008297 Male Males
D010865 Pilot Projects Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work. Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011995 Recombination, Genetic Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses. Genetic Recombination,Recombination,Genetic Recombinations,Recombinations,Recombinations, Genetic
D012127 Respiratory Distress Syndrome, Newborn A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause. Infantile Respiratory Distress Syndrome,Neonatal Respiratory Distress Syndrome,Respiratory Distress Syndrome, Infant
D001997 Bronchopulmonary Dysplasia A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS. Dysplasia, Bronchopulmonary
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response

Related Publications

J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Localization and activity of recombinant human CuZn superoxide dismutase after intratracheal administration.
August 1996, The American journal of physiology,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase.
March 2003, Pediatrics,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Crystallographic characterization of recombinant human CuZn superoxide dismutase.
December 1986, The Journal of biological chemistry,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Effect of long-term penicillamine therapy on erythrocyte CuZn superoxide dismutase activity.
February 1984, Scandinavian journal of clinical and laboratory investigation,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Long-term follow-up of premature infants with urinary tract infection.
September 2021, European journal of pediatrics,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
A calorimetric study of human CuZn superoxide dismutase.
December 1987, The Biochemical journal,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Spectral and physical properties of human extracellular superoxide dismutase: a comparison with CuZn superoxide dismutase.
August 1993, Archives of biochemistry and biophysics,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Follow-up of premature infants treated with indomethacin.
August 1981, The Journal of pediatrics,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Lung CuZn-superoxide dismutase and catalase gene expression in premature rabbits treated intratracheally with antioxidant-surfactant liposomes.
December 1996, Biochemical and molecular medicine,
J M Davis, and S E Richter, and S Biswas, and W N Rosenfeld, and L Parton, and I H Gewolb, and R Parad, and W Carlo, and R J Couser, and S Baumgart, and V Atluru, and L Salerno, and N Kassem
Intracellular uptake of recombinant superoxide dismutase after intratracheal administration.
May 1998, The American journal of physiology,
Copied contents to your clipboard!