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The effect of long-term penicillamine therapy on erythrocyte CuZn superoxide dismutase activity was investigated. For comparison the serum ceruloplasmin and serum copper contents were also analysed. Seven of the 11 penicillamine-treated patients had CuZn superoxide dismutase activities below the reference interval of the parameter. Levels down to about 50% of the mean of controls were observed in several cases. In five and in four of the 11 patients respectively decreases in serum ceruloplasmin and serum copper were found. Whereas among the penicillamine-treated patients there was a good correlation between serum ceruloplasmin and serum copper, the correlation between these parameters and erythrocyte CuZn superoxide dismutase was only fair. Erythrocyte CuZn superoxide dismutase is probably a suitable parameter for monitoring intracellular copper availability during penicillamine therapy.
S L Marklund, and
B Ek, and
L Steen
September 2006,
Biological trace element research,
S L Marklund, and
B Ek, and
L Steen
January 1994,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
S L Marklund, and
B Ek, and
L Steen
August 1994,
Clinical chemistry,
S L Marklund, and
B Ek, and
L Steen
January 2010,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
S L Marklund, and
B Ek, and
L Steen
January 1992,
Pneumonologia i alergologia polska,
S L Marklund, and
B Ek, and
L Steen
April 1999,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
S L Marklund, and
B Ek, and
L Steen
March 2013,
Free radical research,
S L Marklund, and
B Ek, and
L Steen
June 2000,
Journal of perinatology : official journal of the California Perinatal Association,
S L Marklund, and
B Ek, and
L Steen
June 1994,
Annals of the New York Academy of Sciences,
S L Marklund, and
B Ek, and
L Steen
December 1998,
Parasitology,
