-transparent.png){kind=logo}
Macrophage-derived chemokine (MDC) is a CC chemokine paradigmatic of emerging aspects of chemokine immunobiology. It is constitutively expressed, yet microbial products and cytokines regulate its expression with divergent effects of type II (IL-4 and IL-13) and type I (interferon) cytokines. Processing of the mature protein by dipeptidyl peptidase IV/CD26 provides a further level of regulation. It acts on diverse cellular targets including dendritic cells (DC), NK cells, and T cell subsets. Among these, MDC is a potent attractant for CCR4 expressing polarized Th2 and Tc2 cells, and evidence is consistent with a role of this chemokine as an amplification loop of polarized type II responses. Emerging indications on the involvement of MDC in diverse pathologies, ranging from allergic reactions to HIV infection and neoplasia, are discussed.
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
January 2002,
Critical reviews in immunology,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
August 2023,
International journal of molecular sciences,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
November 2006,
Cancer immunology, immunotherapy : CII,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
September 1998,
Journal of immunology (Baltimore, Md. : 1950),
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
February 2002,
Clinical and experimental immunology,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
March 2018,
Clinical chemistry and laboratory medicine,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
November 2006,
Journal of dermatological science,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
January 1999,
Current topics in microbiology and immunology,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
May 1998,
Journal of leukocyte biology,
A Mantovani, and
P A Gray, and
J Van Damme, and
S Sozzani
April 2004,
Journal of immunology (Baltimore, Md. : 1950),
