Biomaterial Database

Regulation of macrophage-derived chemokine (MDC, CCL22) production. 2002

Uki Yamashita, and Etsushi Kuroda

Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan. yama-uki@med.uoeh-u.ac.jp

Macrophage-derived chemokine (MDC, CCL22) is a member of the CC-chemokine family and is composed of 69 amino acid residues. MDC is mainly produced by macrophages and dendritic cells upon the stimulation with microbial products, or anti-CD40 antibody, and is upregulated by TH2-type cytokines, such as IL-4 and -5, but is downregulated by TH1-type cytokines, such as IFN-gamma. MDC-production is also upregulated by prostaglandin and cyclic AMP-elevating agents. MDC causes chemotactic migration of dendritic cells and TH2 cells. Furthermore, MDC is highly-expressed in the lesions of TH2-related diseases, such as airway hypersensitivity and atopic dermatitis. Thus, MDC plays an important role in the recruitment of TH2 cells into the inflammatory sites and the regulation of TH2-related immune responses.

UI	MeSH Term	Description	Entries
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D008807	Mice, Inbred BALB C	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D003876	Dermatitis, Atopic	A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	Eczema, Atopic,Eczema, Infantile,Neurodermatitis, Atopic,Neurodermatitis, Disseminated,Atopic Dermatitis,Atopic Eczema,Atopic Neurodermatitis,Disseminated Neurodermatitis,Infantile Eczema
D005786	Gene Expression Regulation	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.	Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001249	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	Asthma, Bronchial,Bronchial Asthma,Asthmas
D013950	Thymus Gland	A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.	Thymus,Gland, Thymus,Glands, Thymus,Thymus Glands
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D054414	Chemokine CCL17	A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. It is synthesized by DENDRITIC CELLS; ENDOTHELIAL CELLS; KERATINOCYTES; and FIBROBLASTS.	CCL17 Chemokine,TARC Chemokine,Thymus and Activation-Regulated Chemokine,CCL17, Chemokine,Chemokine, CCL17,Chemokine, TARC,Thymus and Activation Regulated Chemokine
D054422	Chemokine CCL22	A CC-type chemokine with specificity for CCR4 RECEPTORS. It has activity towards TH2 CELLS and TC2 CELLS.	CCL22 Chemokine,CC Chemokine STCP-1,Macrophage-Derived Chemokine,SCYA22 Chemokine,Small Inducible Cytokine A22,Stimulated T Cell Chemotactic Protein 1,CC Chemokine STCP 1,CCL22, Chemokine,Chemokine STCP-1, CC,Chemokine, CCL22,Chemokine, Macrophage-Derived,Chemokine, SCYA22,Macrophage Derived Chemokine,STCP-1, CC Chemokine