Biomaterial Database

Analysis and modulation of spike trains and oscillations in identified neural network of Lymnaea stagnalis L. 2000

G Molnár, and A Szücs, and K S Rózsa

Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany. molnarg@tres.blki.hu

Identified neurons and members of functionally characterized clusters of the central nervous system of Lymnaea stagnalis L. were studied. Long-term spike trains (10-100 min) were collected using current clamp method. Firing patterns were analyzed by several mathematical tools e.g.: spike density function (SDF), interspike interval (ISI), Fourier-transform. Both the spike trains and oscillation of firing were modulated by 5HT (2 x 10(-5) M) and mu-opioid peptides (10(-5) M). Co-application of 5HT (2 x 10(-5) M) and DAGO (10(-5) M) turned the firing of the neurons (RPeD1 and A cells) opposite to the running pattern and eliminated the 0.3 Hz oscillation causing a new slow periodicity (0.1-0.05 Hz).

UI	MeSH Term	Description	Entries
D008195	Lymnaea	A genus of dextrally coiled freshwater snails that includes some species of importance as intermediate hosts of parasitic flukes.	Lymnea,Lymnaeas,Lymneas
D009415	Nerve Net	A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.	Neural Networks (Anatomic),Nerve Nets,Net, Nerve,Nets, Nerve,Network, Neural (Anatomic),Networks, Neural (Anatomic),Neural Network (Anatomic)
D004594	Electrophysiology	The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
D004744	Enkephalin, Methionine	One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	Methionine Enkephalin,5-Methionine Enkephalin,Met(5)-Enkephalin,Met-Enkephalin,5 Methionine Enkephalin,Enkephalin, 5-Methionine,Met Enkephalin
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012701	Serotonin	A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.	5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine
D020875	Enkephalin, Ala(2)-MePhe(4)-Gly(5)-	An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.	D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin,DAMGO,2-Ala-4-MePhe-5-Gly-Enkephalin,Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin,D-Ala2-NMe-Phe4-Gly-ol Enkephalin,DAGO,DAGOL,DAMGE,Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-,RX-783006,Tyr-Ala-Gly-(NMe)Phe-Gly-ol,2 Ala 4 MePhe 5 Gly Enkephalin,D Ala2 NMe Phe4 Gly ol Enkephalin,Enkephalin, D-Ala2-NMe-Phe4-Gly-ol,RX 783006