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[Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms]. 2000
A V Fokin, and
P V Afonin, and
I Iu Mikhaĭlova, and
I N Tsygannik, and
T Iu Mareeva, and
V A Nesmeianov, and
W Pangborn, and
N Lee, and
W Duax, and
E Siszak, and
V Z Pletnev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.
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