BIOMAT Database Logo BIOMAT Database Logo

Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. 2000

D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, 400005, Mumbai, India.

We have shown that the basic helix-loop-helix transcription factor Atonal is sufficient for specification of one of the three subsets of olfactory sense organs on the Drosophila antenna. Misexpression of Atonal in all sensory precursors in the antennal disc results in their conversion to coeloconic sensilla. The mechanism by which specific sense organ fate is triggered remains unclear. We have shown that the homeodomain transcription factor Cut which acts in the chordotonal-external sense organ choice does not play a role in olfactory sense organ development. The expression of atonal in specific domains of the antennal disc is regulated by an interplay of the patterning genes, Hedgehog and Wingless, and Drosophila epidermal growth factor receptor pathway.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008957 Models, Genetic Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Genetic Models,Genetic Model,Model, Genetic
D009419 Nerve Tissue Proteins Proteins, Nerve Tissue,Tissue Proteins, Nerve
D009687 Nuclear Proteins Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. Nucleolar Protein,Nucleolar Proteins,Nuclear Protein,Protein, Nuclear,Protein, Nucleolar,Proteins, Nuclear,Proteins, Nucleolar
D011518 Proto-Oncogene Proteins Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. Cellular Proto-Oncogene Proteins,c-onc Proteins,Proto Oncogene Proteins, Cellular,Proto-Oncogene Products, Cellular,Cellular Proto Oncogene Proteins,Cellular Proto-Oncogene Products,Proto Oncogene Products, Cellular,Proto Oncogene Proteins,Proto-Oncogene Proteins, Cellular,c onc Proteins
D004268 DNA-Binding Proteins Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D004331 Drosophila melanogaster A species of fruit fly frequently used in genetics because of the large size of its chromosomes. D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D004815 Epidermal Growth Factor A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. EGF,Epidermal Growth Factor-Urogastrone,Urogastrone,Human Urinary Gastric Inhibitor,beta-Urogastrone,Growth Factor, Epidermal,Growth Factor-Urogastrone, Epidermal,beta Urogastrone
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012679 Sense Organs Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM. Sensory System,Organ, Sense,Sense Organ,Sensory Systems,System, Sensory

Related Publications

D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Atonal is the proneural gene for Drosophila photoreceptors.
June 1994, Nature,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Atonal is a proneural gene for a subset of olfactory sense organs in Drosophila.
March 1997, Genes to cells : devoted to molecular & cellular mechanisms,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
The specificity of proneural genes in determining Drosophila sense organ identity.
August 1998, Mechanisms of development,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system.
July 1993, Cell,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Hierarchical axon targeting of Drosophila olfactory receptor neurons specified by the proneural transcription factors Atonal and Amos.
January 2016, Genes to cells : devoted to molecular & cellular mechanisms,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation.
November 2004, Developmental cell,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Direct control of the proneural gene atonal by retinal determination factors during Drosophila eye development.
January 2008, Developmental biology,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors.
July 1995, Development (Cambridge, England),
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye.
October 1996, Current biology : CB,
D Jhaveri, and A Sen, and G V Reddy, and V Rodrigues
Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal.
November 1996, Genomics,
Copied contents to your clipboard!