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Specific receptors for dihydrotestosterone and estradiol-17-beta have been identified in cytosols of the human and baboon prostate. Binding of radioactive estradiol-17-beta to the 0.4 M potassium chloride extractable component of human prostate nuclei also was demonstrated. Cyproterone acetate and diethylstilbestrol, agents of known high affinity for dihydrotestosterone and estradiol-17-beta receptors, respectively, did not bind significantly to sex hormone binding globulin and, therefore, were useful as competitors in distinguishing binding of dihydrotestosterone and estradiol-17-beta to sex hormone binding globulin and to their specific receptors. Displacement of [3H]-estradiol-17-beta binding by diethylstilbestrol in cytosols of 11 needle biopsy specimens (mean equals 16.8 mg.) from prostatic cancer patients was analyzed. These preliminary data indicated a trend towards greater competition by diethylstilbestrol for high affinity binding sites in differentiated tumor specimens from men who were not receiving estrogen therapy. Objective and subjective responses to hormone therapy were recorded in these patients, whereas the disease in those men with low displacement assay values progressed.
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
January 1979,
Progress in clinical and biological research,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
January 1984,
Vestnik Akademii meditsinskikh nauk SSSR,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
January 1975,
Vitamins and hormones,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
January 1980,
Exposes annuels de biochimie medicale,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
January 1975,
Advances in pathobiology,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
May 1994,
La Revue du praticien,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
January 1991,
Current topics in pathology. Ergebnisse der Pathologie,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
September 1993,
The Journal of laboratory and clinical medicine,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
June 1984,
Archives of disease in childhood,
J P Karr, and
Z Wajsman, and
S Madajewicz, and
R Y Kirdani, and
G P Murphy, and
A A Sandberg
December 2009,
Cancer cell,
