-transparent.png){kind=logo}
The identities of the apical Cl-/base exchangers in kidney proximal tubule and cortical collecting duct (CCD) cells remain unknown. Pendrin (PDS), which is expressed at high levels in the thyroid and its mutation causes Pendred's syndrome, is shown to be an anion exchanger. We investigated the renal distribution of PDS and its function. Our results demonstrate that pendrin mRNA expression in the rat kidney is abundant and limited to the cortex. Proximal tubule suspensions isolated from kidney cortex were highly enriched in pendrin mRNA. Immunoblot analysis studies localized pendrin to cortical brush-border membranes. Nephron segment RT-PCR localized pendrin mRNA to proximal tubule and CCD. Expression studies in HEK-293 cells demonstrated that pendrin functions in the Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange modes. The conclusion is that pendrin is an apical Cl-/base exchanger in the kidney proximal tubule and CCD and mediates Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange.
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
July 2010,
American journal of physiology. Cell physiology,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
January 2017,
Kidney & blood pressure research,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
January 2018,
Frontiers in physiology,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
March 2002,
American journal of physiology. Gastrointestinal and liver physiology,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
May 1993,
The Journal of biological chemistry,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
April 2012,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
December 2004,
American journal of physiology. Renal physiology,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
January 2009,
The journal of medical investigation : JMI,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
January 2016,
PloS one,
M Soleimani, and
T Greeley, and
S Petrovic, and
Z Wang, and
H Amlal, and
P Kopp, and
C E Burnham
December 2003,
American journal of physiology. Gastrointestinal and liver physiology,
