Biomaterial Database

Erythrocyte 2,3-diphosphoglycerate concentrations in hibernating, hypothermic, and rewarming hamsters (38589). 1975

G E Tempel, and X J Musacchia

Hematocrit, hemoglobin and erythrocyte 2,3-DPG concentrations were examined in normothermic control, hibernating, and helium-cold hypothermic hamsters. Hematocrit was not signigicantly different (P greater than 0.05) between groups, but did reflect alterations reported for hemoglobin. Hemoglobin concentration did not change from control values during 12 hr at Tre 7 degrees; however, approximately a 20% decrease occurred in hibernators (48 hrs) and animals hypothermic (24 hr). 2,3-DPG concentrations declined 39.1 and 33.9% from control values in the hibernating and 24 hr hypothermic groups, respectively. No change was observed in animals hypothermic for 12 hr. Both parameters were studied in the aroused animal. Hemoglobin returns to control values immediately after the animals reached a stable Tre approximately equal to 37 degrees. Although 2,3-DPG levels increased during arousal, they were still 10% lower than control values in both metabolically depressed groups. 2,3-DPG remained approximately 10% less than controls in rewarmed hypothermic animals studied 2 hr after reaching stable Tre approximately equal to 37 degrees. The data are discussed in terms of cold depression of erythrocyte glycolysis.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D001831	Body Temperature	The measure of the level of heat of a human or animal.	Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D003080	Cold Temperature	An absence of warmth or heat or a temperature notably below an accustomed norm.	Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D004163	Diphosphoglyceric Acids	Glyceric acids where two of the hydroxyl groups have been replaced by phosphates.	Bisphosphoglycerates,Acids, Diphosphoglyceric
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260	Female		Females
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D006400	Hematocrit	The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.	Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell
D006454	Hemoglobins	The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.	Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous
D006605	Hibernation	The dormant state in which some warm-blooded animal species pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs.	Hibernation, Artificial,Induced Hibernation,Artificial Hibernation,Artificial Hibernations,Hibernation, Induced,Hibernations,Induced Hibernations