BIOMAT Database Logo BIOMAT Database Logo

Metabolism of N-isopropylacetanilide in rat. 2000

G L Larsen, and V J Feil, and J E Bakke
USDA ARS Biosciences Research Laboratory, Fargo, ND 58105, USA. larseng@fargo.ars.usda.gov

1. Radioactivity from oral doses of N-isopropyl[1-14C]acetanilide was excreted in urine (53.5%), faeces (8.1%) and expired air (17.0%) of rat. 2. Enterohepatic circulation occurred during formation of approximately 34% of the metabolites. N-isopropylacetanilide was metabolized by oxidation in all moieties of the molecule with subsequent conjugation with glucuronic and sulphuric acids. 3. The sulphate ester of 4'-hydroxyacetanilide (acetaminophen) was the major metabolite (28 % of the dose).

UI MeSH Term Description Entries
D008297 Male Males
D000083 Acetanilides Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA. Acetylanilines,N-Phenylacetamides
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

G L Larsen, and V J Feil, and J E Bakke
Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the rat.
January 1979, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes,
G L Larsen, and V J Feil, and J E Bakke
Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the sheep and milk goat.
January 1979, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes,
G L Larsen, and V J Feil, and J E Bakke
Enterohepatic circulation in formation of propachlor (2-chloro-N-isopropylacetanilide) metabolites in the rat.
July 1981, Xenobiotica; the fate of foreign compounds in biological systems,
G L Larsen, and V J Feil, and J E Bakke
Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the leaves of corn, sorghum, sugarcane, and barley.
January 1971, Journal of agricultural and food chemistry,
G L Larsen, and V J Feil, and J E Bakke
Metabolism of mercapturic acid-pathway metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by gastrointestinal bacteria.
February 1983, Xenobiotica; the fate of foreign compounds in biological systems,
G L Larsen, and V J Feil, and J E Bakke
Replacement of a chlorine with a methylsulfonyl group in the metabolism of propachlor (2-chloro-N-isopropylacetanilide).
October 1976, Biomedical mass spectrometry,
G L Larsen, and V J Feil, and J E Bakke
Fast atom bombardment mass spectra of mercapturic acid-pathway metabolites of propachlor (2-chloro-N-isopropylacetanilide).
December 1982, Xenobiotica; the fate of foreign compounds in biological systems,
G L Larsen, and V J Feil, and J E Bakke
Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates.
April 1980, Biochemical pharmacology,
G L Larsen, and V J Feil, and J E Bakke
[Metabolism of N heptyl cyclohexylboronate in the rat].
March 1970, Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
G L Larsen, and V J Feil, and J E Bakke
Metabolism of n-hexadecane in myelinating rat brain.
September 1972, FEBS letters,
Copied contents to your clipboard!