BIOMAT Database Logo BIOMAT Database Logo

Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the rat. 1979

J E Bakke, and C E Price

Eleven urinary metabolites from [14C]propachlor were either identified or characterized by mass spectrometry. Those identified were 2-[S-(N-acetyl)cysteinyl]-N-isopropylacetanilide, 2-(methylsulfonyl)-acetanilide, 4'-hydroxy-2-(methylsulfonyl)-acetanilide, and 4'-hydroxyacetanilide. Those characterized were N-(1-hydroxyisopropyl)-2-(methylsulfonyl) acetanilide and its glucuronide, the glucuronides of 4'-hydroxy-N-isopropyl-2-(methylsulfonyl)acetanilide, N-(1-hydroxyisopropyl) aniline, 4'-hydroxy-2-(methylsulfonyl)acetanilide, and either N-(1-hydroxy-isopropyl) acetanilide or 2-hydroxy-N-isopropylacetanilide.

UI MeSH Term Description Entries
D005965 Glucuronates Derivatives of GLUCURONIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the 6-carboxy glucose structure. Glucosiduronates,Glucuronic Acids,Acids, Glucuronic
D006540 Herbicides Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. Algaecide,Algicide,Herbicide,Algaecides,Algicides
D006868 Hydrolysis The process of cleaving a chemical compound by the addition of a molecule of water.
D000083 Acetanilides Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA. Acetylanilines,N-Phenylacetamides
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

J E Bakke, and C E Price
Enterohepatic circulation in formation of propachlor (2-chloro-N-isopropylacetanilide) metabolites in the rat.
July 1981, Xenobiotica; the fate of foreign compounds in biological systems,
J E Bakke, and C E Price
Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the leaves of corn, sorghum, sugarcane, and barley.
January 1971, Journal of agricultural and food chemistry,
J E Bakke, and C E Price
Metabolism of mercapturic acid-pathway metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by gastrointestinal bacteria.
February 1983, Xenobiotica; the fate of foreign compounds in biological systems,
J E Bakke, and C E Price
Fast atom bombardment mass spectra of mercapturic acid-pathway metabolites of propachlor (2-chloro-N-isopropylacetanilide).
December 1982, Xenobiotica; the fate of foreign compounds in biological systems,
J E Bakke, and C E Price
Metabolism of N-isopropylacetanilide in rat.
December 2000, Xenobiotica; the fate of foreign compounds in biological systems,
J E Bakke, and C E Price
In situ intestinal absorption of 2-chloro-N-isopropylacetanilide (propachlor) and non-biliary excretion of metabolites into the intestinal tract of rats, pigs and chickens.
January 1991, Xenobiotica; the fate of foreign compounds in biological systems,
J E Bakke, and C E Price
Evidence for involvement of non-biliary excretion into the intestines in the formation of methylsulphonyl-containing metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by swine and rats.
September 1987, Xenobiotica; the fate of foreign compounds in biological systems,
J E Bakke, and C E Price
Metabolism of propachlor by the germfree rat.
October 1980, Science (New York, N.Y.),
J E Bakke, and C E Price
Metabolism of 6-chloro n-butyl phthalide in rat.
January 1996, European journal of drug metabolism and pharmacokinetics,
J E Bakke, and C E Price
N'-(4-Chloro-o-tolyl)-N-methylformamidine (demethylchlordimeform) metabolism in the rat.
January 1976, Journal of agricultural and food chemistry,
Copied contents to your clipboard!