1,2-disubstituted cyclohexane carbocyclic analogues of nucleosides. 2001

D Viña, and L Santana, and E Uriarte
Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.

Several compounds of a new series of cyclohexane-based 1,2-disubstituted carbonucleoside analogues, were synthesized. The adenine and uridine derivatives, were prepared by construction of the heterocyclic base on the primary amino group of 2-aminocyclohexylmethanol, and the thymine derivative by condensation of 2-hydroxycyclohexylmethanol with thymine using the Mitsunobu reaction.

UI MeSH Term Description Entries
D009705 Nucleosides Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Nucleoside,Nucleoside Analog,Nucleoside Analogs,Analog, Nucleoside,Analogs, Nucleoside
D003510 Cyclohexanes Six-carbon alicyclic hydrocarbons.
D000225 Adenine A purine base and a fundamental unit of ADENINE NUCLEOTIDES. Vitamin B 4,4, Vitamin B,B 4, Vitamin
D013941 Thymine One of four constituent bases of DNA. 5-Methyluracil,5 Methyluracil
D014529 Uridine A ribonucleoside in which RIBOSE is linked to URACIL. Allo-Uridine,Allouridine,Allo Uridine

Related Publications

D Viña, and L Santana, and E Uriarte
September 2002, European journal of medicinal chemistry,
D Viña, and L Santana, and E Uriarte
September 1986, Journal of medicinal chemistry,
D Viña, and L Santana, and E Uriarte
September 1981, Journal of medicinal chemistry,
D Viña, and L Santana, and E Uriarte
January 2003, Nucleosides, nucleotides & nucleic acids,
D Viña, and L Santana, and E Uriarte
October 1984, Journal of medicinal chemistry,
D Viña, and L Santana, and E Uriarte
September 2001, Chemical & pharmaceutical bulletin,
D Viña, and L Santana, and E Uriarte
January 1986, Medicinal research reviews,
D Viña, and L Santana, and E Uriarte
February 1983, Journal of medicinal chemistry,
D Viña, and L Santana, and E Uriarte
July 1995, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
D Viña, and L Santana, and E Uriarte
May 1998, Bioorganic & medicinal chemistry letters,
Copied contents to your clipboard!