-transparent.png){kind=logo}
(1S,1'R)-cis-1-(3'-aminomethyl-2',2'-dimethylcyclobutyl)ethanol (1) and (1S,1'R)-cis-1-[3'-(2-aminoethyl)-2',2'-dimethylcyclobutyl]ethanol (2) were used as precursors in the synthesis of cyclobutyl nucleoside analogues containing adenine and 8-azaadenine moieties, which were tested as antiviral and antitumoral agents in a variety of assay systems. Compounds 8 and 9 displayed significant activity against respiratory syncytial virus, and compounds 14 and 15 were moderately active against vaccinia virus.
Related Publications
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
July 1998,
Nucleosides & nucleotides,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
August 1997,
Archiv der Pharmazie,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
October 1999,
Nucleosides & nucleotides,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
January 2002,
Nucleosides, nucleotides & nucleic acids,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
July 1998,
Nucleosides & nucleotides,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
September 1986,
Journal of medicinal chemistry,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
September 1981,
Journal of medicinal chemistry,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
July 1995,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
January 1999,
Nucleic acids symposium series,
A R Hergueta, and
F Fernandez, and
C López, and
J Balzarini, and
E De Clercq
January 2001,
Nucleosides, nucleotides & nucleic acids,
