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30 patients with chronic tonsillitis (CT) and 20 patients with chronic sinusitis (CS) received likopid (4 mg/day for 10 days). CT patients were additionally treated with tonsil lacunar lavage with dioxidine solution. Likopid was found effective in CT patients (good response--31%, partial response--59%). 9% did not respond to likopid. CS patients benefited less (good response--10%, partial response--50%). 40% were non-responders. In CT patients likopid demonstrated also an immunomodulating effect. Positive changes were observed in the counts of B-lymphocytes, T-lymphocytes, T-helpers, natural killers, level of serum IgG, titers of specific antibodies, functional activity of neutrophils. In CS this effect was less pronounced.
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1998,
Terapevticheskii arkhiv,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1984,
Vestnik otorinolaringologii,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1969,
Vestnik otorinolaringologii,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1973,
Vestnik otorinolaringologii,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1978,
Terapevticheskii arkhiv,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
September 1973,
Pediatriia,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1969,
Vestnik otorinolaringologii,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1970,
Vestnik otorinolaringologii,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
November 1975,
Zeitschrift fur Allgemeinmedizin,
S V Filatova, and
B V Pinegin, and
A V Simonova, and
M E Artem'ev, and
N M Golubeva
January 1972,
Vestnik otorinolaringologii,
