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OBJECTIVE Elucidation of likopid effect on clinical and immunological pictures in patients with chronic bronchitis (CB). METHODS A trial of 52 CB patients in remission and exacerbation. 2 schemes of likopid treatment were used: 1 mg/day for 10 days (a course dose 10 mg); 10 mg/day for 6 days (a course dose 60 mg). Clinical and laboratory parameters, systemic immunity (measurement of lymphocyte subpopulations, levels of serum IgA, IgM and IgG, functional activity of peripheral blood phagocytes). RESULTS The 10 mg and 60 mg courses of likopid produced prolongation of remission to 5-6 months in 66% of CB patients in exacerbation and in 80% of patients in remission, respectively. 10 mg of likopid in exacerbation and 60 mg in remission promoted normalization of functional activity of blood phagocytes. CONCLUSIONS Likopid administration for CB in a 10 mg course dose in exacerbation and 60 mg course in remission prolongs CB remission to 5-6 months and promoted normalization of phagocytic functional activity.
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
January 2001,
Vestnik otorinolaringologii,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
January 1994,
Terapevticheskii arkhiv,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
January 1985,
Terapevticheskii arkhiv,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
March 1983,
Vestnik dermatologii i venerologii,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
March 1983,
Vrachebnoe delo,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
August 1992,
Likars'ka sprava,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
March 1985,
Vrachebnoe delo,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
January 1995,
Likars'ka sprava,
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
January 1998,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
A M Borisova, and
N Kh Setdikova, and
B V Pinegin, and
A V Kulakov, and
N M Golubeva
January 1988,
Terapevticheskii arkhiv,
