Total synthesis of indole and dihydroindole alkaloids. VIII. Studies on the synthesis of bisindole alkaloids in the vinblastine-vincristine series. The chloroindolenine approach.
1975
J P Kutney, and
J Beck, and
F Bylsma, and
J Cook, and
W J Cretney, and
K Fuji, and
R Imhof, and
A M Treasurywala
UI
MeSH Term
Description
Entries
D008722
Methods
A series of steps taken in order to conduct research.
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
Alkaloids, Vinca
D014750
Vincristine
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)