BIOMAT Database Logo BIOMAT Database Logo

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. 2002

Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Ina Sue Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

CCR3 is a chemokine receptor initially thought specific to eosinophils but subsequently identified on TH2 cell subsets, basophils, mast cells, neural tissue, and some epithelia. Because of the prominent role of these cells in allergic disease, including asthma, we generated mice deficient in CCR3 to determine its contribution in a model of allergic airway disease. Here we show that CCR3 is important for the basal trafficking of eosinophils to the intestinal mucosa but not the lung. In contrast, CCR3 disruption significantly curtails eosinophil recruitment to the lung after allergen challenge, with the majority of the eosinophils being arrested in the subendothelial space. Further, a role for CCR3 in mast cell homing has been identified; after sensitization and allergen challenge, we find increased numbers of intraepithelial mast cells in the trachea of knockout mice. Physiologically, we find that the net result of these complex cell fates after sensitization and allergen challenge is a paradoxical increase in airway responsiveness to cholinergic stimulation. These data underscore a more complex role for CCR3 in allergic disease than was anticipated.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008407 Mast Cells Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR. Basophils, Tissue,Basophil, Tissue,Cell, Mast,Cells, Mast,Mast Cell,Tissue Basophil,Tissue Basophils
D010047 Ovalbumin An albumin obtained from the white of eggs. It is a member of the serpin superfamily. Serpin B14
D001992 Bronchoalveolar Lavage Fluid Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung. Alveolar Lavage Fluid,Bronchial Lavage Fluid,Lung Lavage Fluid,Bronchial Alveolar Lavage Fluid,Lavage Fluid, Bronchial,Lavage Fluid, Lung,Pulmonary Lavage Fluid,Alveolar Lavage Fluids,Bronchial Lavage Fluids,Bronchoalveolar Lavage Fluids,Lavage Fluid, Alveolar,Lavage Fluid, Bronchoalveolar,Lavage Fluid, Pulmonary,Lavage Fluids, Alveolar,Lavage Fluids, Bronchial,Lavage Fluids, Bronchoalveolar,Lavage Fluids, Lung,Lavage Fluids, Pulmonary,Lung Lavage Fluids,Pulmonary Lavage Fluids
D004804 Eosinophils Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin. Eosinophil
D006706 Homeostasis The processes whereby the internal environment of an organism tends to remain balanced and stable. Autoregulation
D000485 Allergens Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). Allergen
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016535 Bronchial Hyperreactivity Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory. Bronchial Hyperreactivities,Hyperreactivities, Bronchial,Hyperreactivity, Bronchial

Related Publications

Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
The murine CCR3 receptor regulates both eosinophilia and hyperresponsiveness in IgE-mediated allergic conjunctivitis.
August 2012, The British journal of ophthalmology,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Role of airway eosinophils in the development of allergen-induced airway hyperresponsiveness in dogs.
November 1995, American journal of respiratory and critical care medicine,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Role of mast cells in antigen-induced airway inflammation and bronchial hyperresponsiveness in rats.
March 2001, Japanese journal of pharmacology,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.
June 2006, Allergology international : official journal of the Japanese Society of Allergology,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation.
December 2010, European journal of pharmacology,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Role of the Th2 cytokines in the development of allergen-induced airway inflammation and hyperresponsiveness.
January 1999, International archives of allergy and immunology,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Effect of an inhaled corticosteroid on airway eosinophils and allergen-induced airway hyperresponsiveness in dogs.
September 1994, Journal of applied physiology (Bethesda, Md. : 1985),
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice.
August 2006, The Journal of allergy and clinical immunology,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Requirement for chemokine receptor 5 in the development of allergen-induced airway hyperresponsiveness and inflammation.
December 2011, American journal of respiratory cell and molecular biology,
Alison A Humbles, and Bao Lu, and Daniel S Friend, and Shoji Okinaga, and Jose Lora, and Amal Al-Garawi, and Thomas R Martin, and Norma P Gerard, and Craig Gerard
Role of mast cells, eosinophils and IL-5 in the development of airway hyperresponsiveness in sensitized mice.
June 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Copied contents to your clipboard!