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The role of the eosinophil in the development of allergen-induced airway hyperresponsiveness is uncertain. We examined whether the development of airway hyperresponsiveness in 17 dogs after inhalation of Ascaris suum allergen (10(-6) to 10(-2) weight/volume [w/v]) was associated with increases in the number and level of activation of eosinophils before and after allergen inhalation. Airway responsiveness to inhaled acetylcholine was measured before and 24 h after Ascaris inhalation. Eosinophil number was assessed by bronchoalveolar lavage performed 1 wk before allergen inhalation and 15 min after the 24 h acetylcholine challenge. Dogs that developed Ascaris-induced airway hyperresponsiveness (n = 8) had a significantly greater number of bronchoalveolar lavage eosinophils before allergen inhalation (mean +/- SEM: 4.6 +/- 1.94 x 10(4) cells/ml) than dogs that did not become hyperresponsive (n = 9) (1.2 +/- 0.81 x 10(4) cells/ml) (p = 0.03). Ascaris-induced airway hyperresponsiveness, measured 24 h after allergen inhalation, was not associated with increases in eosinophil number after allergen challenge. These results suggest that the presence of airway eosinophils before allergen inhalation is necessary for the development of allergen-induced airway hyperresponsiveness.
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
September 1999,
International archives of allergy and immunology,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
January 1988,
The Journal of allergy and clinical immunology,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
January 1999,
International archives of allergy and immunology,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
April 2009,
American journal of respiratory cell and molecular biology,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
February 2002,
Proceedings of the National Academy of Sciences of the United States of America,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
January 1998,
Allergy and asthma proceedings,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
October 1997,
American journal of respiratory and critical care medicine,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
July 1993,
Journal of applied physiology (Bethesda, Md. : 1985),
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
June 2006,
Allergology international : official journal of the Japanese Society of Allergology,
M J Woolley, and
C G Lane, and
R Ellis, and
W H Stevens, and
K L Woolley, and
P M O'Byrne
May 1995,
American journal of respiratory and critical care medicine,
