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An indirect solid-phase radioimmunoassay (RIA) for detection of antibody to the hepatitis A antigen (anti-HAV) was developed using polystyrene pearls as the solid phase and hepatitis A antigen (HAAg) extracted from marmoset livers. This RIA was compared to an immune adherence hemagglutination assay (IAHA) which employed HAAg derived from the stools of chimpanzees collected during acute hepatitis A. Anti-HAV was detected in the sera of 15 humans with naturally acquired hepatitis A infection. Sensitivity and specificity were greater using the RIA, permitting the detection of anti-HAV as early as the time of onset of jaundice. Either seroconversion or a significant increase in the titer of anti-HAV was demonstrated following hepatitis A exposure in paired sera from six patients by both techniques. No significant difference in anti-HAV responses was noted between patients with icteric compared to anicteric hepatitis A or between children and adults with hepatitis A.
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
December 1976,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
September 1978,
Journal of the American Veterinary Medical Association,
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
September 1984,
The Southeast Asian journal of tropical medicine and public health,
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
March 1976,
Infection and immunity,
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
April 1976,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
August 1993,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
February 1978,
Journal of clinical microbiology,
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
September 1975,
Journal of immunology (Baltimore, Md. : 1950),
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
June 1975,
Journal of immunological methods,
J Drucker, and
L Smallwood, and
D Lorenz, and
E Tabor, and
P Coursaget, and
P Maupas, and
L F Barker, and
R J Gerety
January 1982,
Journal of clinical microbiology,
