-transparent.png){kind=logo}
1. The anti-inflammatory agent diclofenac sodium (o-[(2,6-dichlorophenyl)amino]phenylacetic acid sodium salt) is extensively metabolized by rat, dog, baboon and man. The main metabolites were isolated from the urine of all species and from the bile of rat and dog and identified by spectroscopy. 2. Metabolism involves direct conjugation of the unchanged drug, or oxidation of the aromatic rings usually followed by conjugation. Sites of oxidation are either position 3' or 4' of the dichlorophenyl ring or, alternatively, position 5 of the phenyl ring attached to the acetic acid moiety. 3. In the urine of rat, baboon and man conjugates of the hydroxylated metabolites predominate, but the major metabolite in dog urine is the taurine conjugate of unchanged diclofenac. 4. In the bile of rat and dog, the main metabolite is the ester glucuroniade of unchanged diclofenac.
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
November 1985,
Seminars in arthritis and rheumatism,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
February 1991,
The American journal of gastroenterology,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
February 1984,
Die Pharmazie,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
February 2000,
Harefuah,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
May 1984,
Biomedical mass spectrometry,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
January 1982,
Biomedical mass spectrometry,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
January 1983,
Zeitschrift fur Rheumatologie,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
January 1976,
Drug metabolism and disposition: the biological fate of chemicals,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
January 1979,
Rheumatology and rehabilitation,
H Stierlin, and
J W Faigle, and
A Sallmann, and
W Küng, and
W J Richter, and
H P Kriemler, and
K O Alt, and
T Winkler
January 1995,
Acta chirurgica Hungarica,
