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This paper deals with the isolation and identification of hexapropymate metabolites in man. This hypnotic drug is hydroxylated on different positions of the cyclohexane nucleus as was shown by IR, 1H-NMR and MS data of the isolated metabolites and their hydrolysis products. For the determination of the position and conformation of the metabolically introduced hydroxyl group, it was necessary to synthesize different reference compounds [12] and compare their physico-chemical data with those of the isolated metabolites. In this way the following phase-I-metabolites could be identified: 4a-hydroxy-1-(2'propynyl)cyclohexanol-1-carbamate (4a-hydroxyhexapropymate), 4e-hydroxy-1-(2'propynyl)cyclohexanol-1-carbamate (4e-hydroxyhexapropymate) and 3e-hydroxy-1-(2'propynyl)cyclohexanol-1-carbamate. The first two metabolites are also partially excreted in the form of glucuronides.
L Leyssens, and
M van Boven, and
P Daenens
May 1984,
Biomedical mass spectrometry,
L Leyssens, and
M van Boven, and
P Daenens
October 1979,
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L Leyssens, and
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February 1974,
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L Leyssens, and
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P Daenens
January 1967,
International journal of neuropharmacology,
L Leyssens, and
M van Boven, and
P Daenens
July 1981,
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L Leyssens, and
M van Boven, and
P Daenens
January 1982,
Biomedical mass spectrometry,
L Leyssens, and
M van Boven, and
P Daenens
September 1977,
Il Farmaco; edizione scientifica,
L Leyssens, and
M van Boven, and
P Daenens
August 1986,
Xenobiotica; the fate of foreign compounds in biological systems,
L Leyssens, and
M van Boven, and
P Daenens
January 1976,
Drug metabolism and disposition: the biological fate of chemicals,
L Leyssens, and
M van Boven, and
P Daenens
January 1980,
Drug metabolism and disposition: the biological fate of chemicals,
