BIOMAT Database Logo BIOMAT Database Logo

Comparative study of sister chromatid exchange induction and antitumor effects by homo-aza-steroidal esters of [p-[bis(2-chloroethyl)amino]phenyl]butyric acid. 2001

C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Laboratory of Pharmaceutical Chemistry, Patras, Greece.

The present work was undertaken in order to test the hypothesis that the Sister Chromatid Exchange (SCE) assay in vitro can be used for the prediction of in vivo tumor response to newly synthesized potential chemotherapeutics. The effect of three homo-aza-steroidal esters containing the -CONH- in the steroidal nucleus, 1, 2, and 3 on SCE rates and on cell kinetics in cultured human lymphocytes was studied. The antitumor activity of these compounds was tested on leukemia P388- and leukemia L1210-bearing mice. The three substances induced statistically significant enhancement of SCEs and of cell division delays. Compounds 1 and 3 were identified, on a molar basis, as more effective inducers of SCEs and of cell division delays compared with compound 2. Compounds 1 and 3 had upon both experimental tumors better therapeutic effects compared with compound 2 at equitoxic doses. Therefore, the order of the antitumor effectiveness of the three compounds coincided with the order of the cytogenetic effects they induced.

UI MeSH Term Description Entries
D007939 Leukemia L1210 An experimental LYMPHOCYTIC LEUKEMIA of mice. Leukemia L 1210,L 1210, Leukemia,L1210, Leukemia
D007941 Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene. P388D(1) Leukemia,P388, Leukemia
D008297 Male Males
D008811 Mice, Inbred DBA An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004273 DNA, Neoplasm DNA present in neoplastic tissue. Neoplasm DNA
D004354 Drug Screening Assays, Antitumor Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals. Anticancer Drug Sensitivity Tests,Antitumor Drug Screens,Cancer Drug Tests,Drug Screening Tests, Tumor-Specific,Dye Exclusion Assays, Antitumor,Anti-Cancer Drug Screens,Antitumor Drug Screening Assays,Tumor-Specific Drug Screening Tests,Anti Cancer Drug Screens,Anti-Cancer Drug Screen,Antitumor Drug Screen,Cancer Drug Test,Drug Screen, Anti-Cancer,Drug Screen, Antitumor,Drug Screening Tests, Tumor Specific,Drug Screens, Anti-Cancer,Drug Screens, Antitumor,Drug Test, Cancer,Drug Tests, Cancer,Screen, Anti-Cancer Drug,Screen, Antitumor Drug,Screens, Anti-Cancer Drug,Screens, Antitumor Drug,Test, Cancer Drug,Tests, Cancer Drug,Tumor Specific Drug Screening Tests
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Antitumor activity of homo-aza-steroidal esters of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid and [p-[bis(2-chloroethyl)amino]phenyl]butyric acid.
January 1983, Cancer chemotherapy and pharmacology,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Antitumor activity of homo-aza-steroidal esters of p-N, N-bis(2-chloroethyl)aminophenoxyacetic acid.
January 1993, Anticancer research,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Antitumor activity of a homo-aza-steroidal ester of (p-(bis(2-chloroethyl)amino)phenyl)acetic acid (NSC-71964).
January 1973, Cancer chemotherapy reports,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Antileukemic effect of homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid.
January 1977, Cancer treatment reports,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Effects of homo-aza-steroidal ester of p-bis(2-chloroethyl)amino phenyl acetic acid on lymphocytes stimulated with phytohemagglutinin in vitro.
July 1978, Journal of steroid biochemistry,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Induction of sister chromatid exchanges and cell division delays in human lymphocytes by the anti-tumour agent homo-aza-steroidal ester of p-bis(2-chloroethyl)aminophenoxy acetic acid.
September 1989, Mutagenesis,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Interaction of homo-aza-steroidal ester of [p-[bis-(2-chloroethyl) amino]phenyl]acetic acid (ASE) with DNA of Ehrlich ascites tumor cells.
March 1983, FEBS letters,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Further study on the antitumor activity of a homo-aza-steroidal ester of p-N,N-bis(2-chloroethyl)aminophenylacetic acid.
November 1990, Journal of pharmaceutical sciences,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Studies on the effect of homo-aza-steroidal ester of p-bis (2-chloroethyl) amino phenyl acetic acid in Ehrlich ascites tumor cells.
January 1984, Methods and findings in experimental and clinical pharmacology,
C Camoutsis, and D Catsoulacos, and V Karayiann, and A Papageorgiou, and D Mourelatos, and E Mioglou, and Z Kritsi, and S Nikolaropoulos
Mutagenicity of four homo-aza-steroidal esters of m-N,N-bis(2-chloroethyl)aminocinnamic acid in the Ames test.
December 1993, Mutation research,
Copied contents to your clipboard!