-transparent.png){kind=logo}
A cytostatic, homo-aza-steroidal ester of [p-[bis-(2-chloroethyl) amino]phenyl]acetic acid (ASE) was reduced with NaB3H4 and [3H]ASE-treated DNA prepared in vitro. We found that: (1) ASE reacts preferentially with purines; (2) ASE decreases the thermal stability of the double helix upon binding to DNA; (3) [3H]ASE binding sites are clustered along the DNA molecules; (4) ASE binding sites probably represent oligo- or polypurine sequences.
Related Publications
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
January 1984,
Methods and findings in experimental and clinical pharmacology,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
January 1977,
Cancer treatment reports,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
January 1983,
Cancer chemotherapy and pharmacology,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
January 1973,
Cancer chemotherapy reports,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
July 1978,
Journal of steroid biochemistry,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
January 1983,
Environmental mutagenesis,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
January 2001,
Cancer detection and prevention,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
January 1993,
Anticancer research,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
December 1993,
Mutation research,
A Papageorgiou, and
I G Ivanov, and
G G Markov, and
S I Koliais, and
L Boutis, and
P Catsoulakos
November 1990,
Journal of pharmaceutical sciences,
