Biomaterial Database

Development of platelet secretory granules. 2002

Sarah M King, and Guy L Reed

Cardiovascular Biology Laboratory, Harvard School of Public Health, Bldg. II-127, 677 Huntington Ave., Boston, MA 02115, USA.

Platelet granule exocytosis plays a critical role in thrombosis and wound healing. Platelets have three major types of secretory granules that are defined by their unique molecular contents, kinetics of exocytosis and morphologies. Although the ontogeny of platelet granules is poorly understood, a convergence of new insights into megakaryocyte development, the molecular mechanisms of vesicle trafficking and the genetic basis of platelet granule defects, is beginning to define the cellular and molecular pathways responsible for platelet granule ontogeny.

UI	MeSH Term	Description	Entries
D008247	Lysosomes	A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured or undergoes MEMBRANE FUSION. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed).	Autolysosome,Autolysosomes,Lysosome
D001792	Blood Platelets	Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.	Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D022142	Secretory Vesicles	Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.	SLMVs,Secretory Granules,Synaptic Like Microvesicles,Synaptic-Like Microvesicles,Zymogen Granules,Condensing Vacuoles,Condensing Vacuole,Granule, Secretory,Granule, Zymogen,Microvesicle, Synaptic-Like,Secretory Granule,Secretory Vesicle,Synaptic Like Microvesicle,Synaptic-Like Microvesicle,Vacuole, Condensing,Vesicle, Secretory,Zymogen Granule